Enduring effect of scopolamine on memory impairment has been shown by seifhosseini and colleague recently 24. Jul 01, 2004 on the other hand, the scopolamine induced amnesia cannot be reversed by posttreatment with heat shock. Antiamnesic effect of aqueous extract of crataeva nurvala. In the present study, the effect of dl0410 on scopolamine induced learning and memory. The present study examined whether amnesia induced by scopolamine could be counteracted in mice by arecoline, a cholinergic agonist, or by other drugs, epinephrine or glucose, which have been found to enhance memory in aged rodents and humans. Scopolamine 3 mgkg ip given before an acquisition trial, reduced the retention of a onetrial passive avoidance step through response in mice. Effect of betaalanine on transferlatency tl of young mice using elevated plusmaze. Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs.
We used a total of 50 mice in the morris water maze test with 10 mice per treatment. Nootropic activity of ajuga bracteosa wall on scopolamine. Reduced cholinergic transmission may be responsible, at least in part, for the cognitive deficits in models of scopolamine induced amnesia. The animal model of scopolamine scop induced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment in neurodegenerative diseases. This article is from journal of exercise rehabilitation, volume 10. Memoryenhancing activity of palmatine in mice using. Enduring amnesia induced y icv scopolamine is reversed y sesame oil in male rats acta cirurgica brasileira vol. Genistein ameliorates scopolamineinduced amnesia in mice through the regulation of the cholinergic neurotransmission, antioxidant system and the erkcrebbdnf signaling. Hippocampal memory enhancing activity of pine needle.
Hence it was concluded the plant extract possessed neuroprotective activity in the scopolamine induced cognitive decline in mice thereby used as cost effective natural medicines in near fu ture. We report seven experiments in young adult mice which examine scopolamines effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. Decursin from angelica gigas mitigates amnesia induced by. However, the influence of noni on cholinergic system has not been explored so far. Thirtysix male balbc mice weighing around 2535 g were employed in the present investigation. May 14, 2012 the drug, called scopolamine, also known as the devils breath, is derived from a particular type of tree common in colombia called the borrachero tree. The present study examined whether amnesia induced by scopo lamine could be counteracted in mice by arecoline, a choli nergic agonist, or by other drugs. However, there is no report about the effects of ge on scopinduced amnesia in mice. Male c57bl6 mice 2025 g, 8 weeks old were purchased from the dae han bio link. Pass assisted prediction and pharmacological evaluation of. In this study we wanted to test if scopolamine induced.
Antiamnesic activity of vitex negundo in scopolamine. Effect of resveratrol on scopolamineinduced cognitive. Neuroprotective effects of soy isoflavones on scopolamine. In conclusion, the present study revealed that soy isoflavones have neuroprotective effects on scopolamineinduced memory impairments in mice and these effects may be partially due to the enhancement of cholinergic system function, suppression of oxidative stress and activation of the erkcrebbdnf signaling pathway. Memory impairment was induced by scopolamine 4 mgkg, i. However, there is no report about the effects of ge on scopolamine scopinduced amnesia in mice.
Effects of nootropic drugs in a scopolamineinduced amnesia. American ginseng extract reduces scopolamineinduced amnesia. Gongjindan enhances hippocampal memory in a mouse model of scopolamine induced amnesia. Evaluation of neuroprotective effect of quercetin with donepezil in. Frontiers cognitive enhancer effects of low memantine. Additionally, we also established that the positive effects of os extract could be mediated via the bdnftrkb pathway, crebbdnf pathway and also the hippocampal. Results showed that saffrontreated mice exhibited significant improvement. Scopolamine induced amnesia has been proposed as a model. Successive maceration of the plant was made using nhexane followed by methanol solvent to extract out active principles according to their solubility. Naringenin protects against scopolamineinduced dementia. We have investigated the neuroprotective and memory enhancing effect of 6gingerol gin, a pungent ingredient of ginger, using an animal model of amnesia.
Pdf neuroprotective effects of chlorogenic acid on. The present study was designed to determine whether t. Neuroprotective effects of chlorogenic acid on scopolamine. Interestingly, sulforaphaneenriched broccoli sprouts improved the scopolamine induced memory impairment in mice through nrf2 activation, inhibiting neuronal apoptosis particularly through inhibition of caspase3 activation which could lead to the neuroprotection against neurodegenerative disorders. Antiamnesic effects of a hydroethanolic extract of crinum.
Scopolamin e induced mice models with learning and memory impairments have been considered as acetylcholine system impairments and employed extensively to evaluate the memoryenhancing effects of new drugs. Read attenuation of scopolamineinduced amnesia in mice, psychopharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. After 4 weeks of feeding the appropriate diet, scopolamine 1 mgkg, i. Naringenin protects against scopolamineinduced dementia in rats. Amelioration of scopolamineinduced learning and memory. Mice were allowed free access to food and fresh water during. Crinum macowanii has been found to contain alkaloids that have activity against acetylcholinesterase enzyme in vitro. Os extract contains many active compounds that have been shown to possess various pharmacological. Moreover, previous genetic studies have demonstrated that the activation of the campresponse element binding protein creb plays a critical role by turning on the molecular switch of the brainderived neurotrophic factor bdnf for longterm memory. The standardized aqueous extract of crataeva nurvala aecn was freshly dissolved in distilled water and administered orally to rats at the dose of 500 mgkg for evaluation of its effects against scopolamine 3 y. Scopolamineinduced amnesia can be prevented by heat shock.
The dysfunctions are reversible by physostigmine but not by damphetamine which suggests that the memory impairment is specifically related to reduced cholinergic transmission caused by scopolamine. Scopolamine induced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. These finding suggested that pineapple had a protective role against scopolamineinduced amnesia, indicating its ability in management of cognitive disorders. Hippocampal memory enhancing activity of pine needle extract against scopolamineinduced amnesia in a mouse model skip to main content thank you for visiting. Brahmi is one such antiamnesic agent that is frequently used in the ancient indian medical system. Memory enhancer mouse pdf memoryenhancing effects in male mice of pregnenolone and steroids metabolically derived from it. During training, the mice were placed in the conditioning cage 26 cm long, 28 cm wide, and 15 cm high for 60 sec for adaptation. Bhattacharya1 1 department of pharmacology, university college of medical sciences and gtb hospital, new delhi 110095. Gongjindan enhances hippocampal memory in a mouse model of. The cognitiveenhancing activity of the ite 5, 10 and 20. Scopolamineinduced amnesia in young adult human subjects has been considered as a model of senile amnesia ever since drachman and leavitt. Taken together, this study strongly showed that gjd exerted antiamnesic actions in a mice model of scopolamineinduced amnesia.
Indigofera tinctoria linn fabaceae attenuates cognitive. A study on scopolamine amnesic mice bioline international. Scopolamine treated normal young human subjects exhibit memory dysfunctions analogous to those observed in demented patients. Abstractfructus akebiae fae is a component of traditional chinese medicines used for the. Amnesia induced by scopolamine has been widely used to understand the biochemical and behavioral changes in rodents. In the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. The animal model of scopolamine scopinduced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment. Amelioration of scopolamineinduced learning and memory impairment by. Hence it was concluded the plant extract possessed neuroprotective activity in the scopolamine induced cognitive decline in mice thereby used as cost effective natural medicines in near future. The protective effect of fermented curcuma longa l. The underlying mechanisms involve the regulation of the hippocampal cholinergic system and neurogenesis via activation of bdnf.
May 14, 2015 hippocampal memory enhancing activity of pine needle extract against scopolamine induced amnesia in a mouse model skip to main content thank you for visiting. Deb, debasree and nayak, veena and bairy, kl and rao, mohandas kg and shetty, jeevan and hegde, mangala v and koshy, salini s 20 antiamnesic and neuroprotective effects of low dose of ramipril and losartan in scopolamine induced amnesia model of dementia. Antiamnesic and neuroprotective effects of low dose of. Neuroprotective effects of chlorogenic acid on scopolamine induced amnesia via antiacetylcholinesterase and antioxidative activities in mice. Neuroprotective effect and molecular mechanism of 6. To examine the antiamnesic effect of hsp72 overexpression, three groups of animals were subjected to scopolamine injection 30 min before the training trial or 30 min before the retention test 11. Lu c, wang y, xu t, li q, wang d, zhang l, fan b, wang f, liu x. A single administration of cholinergic agonists such as oxotremorine, bm5, or arecoline, antagonized this amnesic effect of scopolamine.
Besides disturbance of acetylcholine metabolism in memory loss, recent. Pdf neuroprotective effects of soy isoflavones on scopolamine. It was also revealed that repeated administration of imperatorin at the doses of 5 and 10 mgkg significantly improved impairment of memory and learning processes induced by acute injection of scopolamine p scopolamine treated mice fig. After 30 min, amnesia was induced in mice with scopolamine 0. S gill, sahil kakkar department of pharmacology, rayat institute of pharmacy. Mice were treated with distilled water or cga 0, 3, 6, or 9 mgkg, p. To determine if ht1001, an extract of american ginseng, affects scopolamine induced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations. Nootropic activity of ajuga bracteosa herb was investigated using scopolamine induced amnesia memory deficits, elevated plusmaze epm and morris water maze mwm experimental models in swiss albino mice. Kshirsagar1 1sudhakarrao naik institute of pharmacy, pusad,m. This study was carried out to examine the effects of ethanol extract expg and saponin sap from platycodon grandiflorum on scopolamineinduced amnesia in mice. Ethanol extract and saponin of platycodon grandiflorum. In the present study, the capability of dl0410 in ameliorating the amnesia induced by scopolamine was investigated, and its effect on the cholinergic system in the hippocampus and its binding mode in the active site of ache was also explored.
Memoryenhancing effect of a supercritical carbon dioxide. The results were similar to the previously reported cognitive enhancement effects of total soy isoflavones at the dose of 40 mgkg in the scopolamineinduced amnesia model. Furthermore, this dose significantly reversed the mapa do parana. The present study demonstrated that sulforaphane is able to protect mice from scopolamine induced learning and memory impairment as. Hence, these findings suggest that heat shock pretreatment has a protective, rather than therapeutic, effect on the scopolamine induced amnesia.
Aim of the study was to evaluate the antiamnesic effects of crataeva nurvala stem bark in scopolamine induced amnesia in rats. Dl0410 ameliorates memory and cognitive impairments. Memoryenhancing activity of palmatine 1 mgkg was comparable to physostigmine. Terminalia chebula extract prevents scopolamineinduced amnesia. Wistar rats 180200 g were trained on active avoidance task.
Ameliorating effect of lyophilized extract of butea. Male c57bl6 mice 2025 g, 8 weeks old were purchased from the dae han biolink. A significant antiamnesic effect was also found with nootropic drugs such as piracetam and ucb l059. Read peripherally administered gmcsf interferes with scopolamineinduced amnesia in mice. Cognitive enhancing of pineapple extract and juice in. Alzheimers disease ad is a chronic neurodegenerative brain disease which is characterized by impairment in cognitive functioning.
Europe pmc is an archive of life sciences journal literature. Scopolamineinduced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. Both the expg groups and the sap group exhibited significant amelioration of scopolamine induced amnesia as measured in both the passive avoidance task and the morris water maze task. Therefore, present study was designed to investigate effect of noni fruit on memory, cerebral blood flow cbf, oxidative stress and acetylcholinesterase ache activity in scopolamine induced amnesia model. The cognitiveenhancing activity of the ide 10, 20 and 40. Effects of nootropic drugs in a scopolamineinduced. Alanine protects mice from memory deficits induced by. The present study deals with the evaluation of potential effects of eclipta alba ea in memory impairment of mice. Ganglioside gm1 attenuates scopolamineinduced amnesia in. To study acquision, consolidation and recall stages of memory, aterials and methods.
Each column, center line in the column and the bars. Abstractalzheimers disease is the most common neurodegenerative disease and this disease. The scopolamine induced amnesia model is commonly used for screening memory enhancing drugs. Sulforaphaneenriched broccoli sprouts pretreated by. Genistein ameliorates scopolamineinduced amnesia in mice. Synergistic effects of galantamine and memantine in. Jangloganin improves learning and memory impairments induced by scopolamine in mice. Effects of imperatorin on scopolamineinduced cognitive.
Gm1sco and salsal but not salsco mice spent significantly less time in the aversive enclosed arm of the discriminative avoidance apparatus when compared to the time spent in the nonaversive enclosed arm. Decursin from angelica gigas mitigates amnesia induced by scopolamine in mice article in neurobiology of learning and memory 791. In the present study, we evaluated the memoryenhancing effects of tce on scopolaminetreated mice using the morris water maze test. Effects of moringa oleifera seed extract mse on scopolamine induced memory impairments on the stepdown test. Lamiaceae is a medicinal plant found around southeast asia that has been employed as treatments for various diseases.
Antiamnesic activity of vitex negundo in scopolamine induced. Gongjindan enhances hippocampal memory in a mouse model. Terminalia chebula extract prevents scopolamineinduced. Prediction of probable antidementia and free radical scavenging activities pa of compounds and their inactivity for the mentioned effects pi using pass software. Zimmerberg 1972, aniracetam and piracetam cumin et al.
Peripherally administered gmcsf interferes with scopolamine. Results showed that juice and ethanolic extract of pineapple significantly restored object recognition ability in mice treated with scopolamine. Scopolamineinduced deficits in cognitive performance. Moringa oleifera seed extract alleviates scopolamine. Protective effect of fruits of morinda citrifolia l. Frontiers ethanolic extract of orthosiphon stamineus. However, opposite situation was observed in the scopolamine amnesia mice. International journal of pharmtech research coden usa. This article is from experimental and therapeutic medicine, volume 8. Memory impairment was induced by scopolamine 3 mgkg, i. Bacopa monniera attenuates scopolamineinduced impairment. Effects of nootropic drugs in a scopolamineinduced amnesia model. Hippocampal memory enhancing activity of pine needle extract.
Palmatine 1 mgkg significantly reversed scopolamine and diazepam induced amnesia in mice. Short communication effect of resveratrol on scopolamineinduced cognitive impairment in mice rachna gupta1, lalit k. In conclusion, the present work demonstrated that os extract was able to revert the scopolamine induced amnesia in the rats thus further distinguishing its antiamnesic effects. We have earlier reported the reversal of diazepam induced amnesia with b. Oct 12, 2018 the animal model of scopolamine scopinduced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment in neurodegenerative diseases. The results are consistent with the interpretation that gm1 attenuates scopolamineinduced amnesia. Animal model of alzheimers disease scopolamine induced.
Aug 02, 2016 taken together, this study strongly showed that gjd exerted antiamnesic actions in a mice model of scopolamineinduced amnesia. Deficits induced by scopolamine in 3 mouse strains as assayed in the tmaze. Synergistic effects of galantamine and memantine in attenuating scopolamineinduced amnesia in mice. Gongjindan enhances hippocampal memory in a mouse model of scopolamineinduced amnesia jinseok lee, affiliation liver and immunology research center, oriental medical collage of daejeon university, 225 daehungdong, junggu, daejeon, 301724, republic of korea. To evaluate the effect of lyophilized hydroalcoholic extract of bf leaves bfle at 100, 200 and 400mgkg, p. Oh, usa according to the manufacturers manual instruction. Neuroprotective effects of soy isoflavones on scopolamineinduced amnesia in mice. Scopolamineinduced cognitive deficits were significantly reversed by ide p scopolamine induced amnesia is a very well recognized animal model of memory dysfunction, widely used to test potential drugs of antialzheimers properties 23. Antiamnesic effect of the bfle was evaluated using morris water maze and object recognition. The present study was undertaken to investigate the in vivo ability of hydroethanolic crude extract of crinum macowanii to ameliorate memory impairment induced by scopolamine. The ameliorating effect of myrrh on scopolamineinduced. Memory enhancing effects of saffron in aged mice are correlated with antioxidant.
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